Background: The nursing diagnosis is a clinical trial of the responses from the individual, his family and the community to health issues, providing an effective basis on the selection of nursing interventions. Objective: This is a descriptive exploratory study, aimed at identifying the most frequent Nursing diagnoses, and proposing specific interventions at home for individuals with chronic illness. Method: The subjects were individuals in the extension project "Home care and support for families of chronic patients." Data was collected from medical records registered by the project participants after each visit. Following, the nursing diagnoses of each patient were obtained through NANDA Taxonomy II. Throughout the analysis of the diagnoses, the most frequent and possible interventions to be proposed were elected. Results: The most frequent diagnoses were: lack of self-care, impaired physical mobility, deficits of recreation activities, and impaired skin integrity. The proposed interventions consisted of providing information to the patient and family on issues such as: proper diet, physical activities, changing in lifestyle and proper use of medications. Implications on Nursing: Identifying nursing diagnoses in the home context allows more recognition to the role of the family on the care for an individual with a chronic disease, providing better quality of life and thus, avoiding rehospitalization due to inadequate care management.