Case study which aimed to describe a home care nurse's experience on transpersonal care to family members of a neonate discharged from an intensive care unit. Transpersonal Care Theory was used as theoretical landmark operationalized by means of Lacerda's Caring Process (1996). A family was selected as the study subject, being followed up during the child's hospitalization and at home after discharge. Data collection was carried out by means of documents and file registers which encompassed methodological notes and the researcher's field diary. It was used general analytical strategy "based on theoretical propositions", for evidence analysis, and "pattern adequation" as specific analytical strategy. Thus, it was possible to evidence family caregivers' caring practices, the importance of nursing in the process of hospitalization, discharge and home care and, additionally, of a theoretical background which guides nurse's actions and matches their way of thinking and acting in the world, mainly towards caring of the self and the other. This path enabled to realize that objective caring actions must come along with human, expressive caring so that nurses behave differently in relation to family caregivers, and also the need of research investmentes capable of bringing along home care and transpersonal care in nursing and other health professions.