Molecular assessment of Mycobacterium leprae - infection and disease in contacts: a systematic review protocol
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Keywords

Hanseníase
Monitoramento Epidemiológico
Epidemiologia Molecular Leprosy
Epidemiologic Monitoring
Molecular Epidemiology

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Abstract

Objective: To analyze the relationship between the presence and molecular viability of Mycobacterium leprae in the bodies of contacts of leprosy cases and the process of infection and disease in these contacts. Method: This systematic review protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines and registered in PROSPERO under CRD42022381295. MEDLINE databases were searched via PubMed, Embase, Cochrane Library, LILACS via BVS, Scopus, and Web of Science. Search terms were selected from MeSH, DeCS, and Emtree thesauruses. The search strategy was designed to retrieve studies that included at least one of the following terms: “Leprosy,” “Presence and Molecular Viability of Mycobacterium leprae,” and “Contact Transmission.” Two pairs of reviewers will select the study, with disagreements resolved by a third reviewer. Two independent reviewers will extract and enter data from the selected studies into a standardized table. A descriptive synthesis of the results will be performed narratively for each category formed. The methodological quality of the included studies will be assessed using the Newcastle-Ottawa scale.

https://doi.org/10.17665/1676-4285.20246764
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References

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